Welcome to the Mruk Lab

Research
Central nervous system (CNS) injuries affect multiple cell types and after the initial damage, additional tissue loss exacerbates the injury leading to permanent dysfunction. There is no effective cure for CNS injuries often leading to a lifetime of therapy and permanent disability. The Mruk Lab studies CNS injuries using the zebrafish because although the zebrafish CNS shares many organizational, cellular and molecular pathways with mammals, functional recovery occurs after injury. We use a combination of electrophysiology, fluorescent imaging, behavior, and bioinformatics to understand how the entire CNS network responds and subsequently recovers from injury.

Zebrafish models of regeneration
Cellular response to spinal cord injury


Optogenetic technologies for studying development and regeneration
Collaborations

People
Karen Mruk
PI

Payge Hoffman
Physiology Undergraduate

Shannon Linch
Chemical Engineering Undergraduate

Andrew Navarro
WWAMI Student

Garret Phillips
Physiology Undergraduate

Ronnie Porter
Fish Extraordinaire

Emily Purifoy
Veterinary Sciences Undergraduate

Kodi Stringer
Physiology Undergraduate

Kirsten Underwood
PharmD Student

Whitney Walker
PhD Student, Biomedical Sciences

Emily Wolf
Physiology Undergraduate

Publications
2020
Mruk, K.*, Ciepla, P., Piza, P. A., Alnaqib, M. A., and Chen, J. K.* (2020) Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development, 147: dev183640 [Pubmed]
2018
Hwang, S., Mruk, K., Rahighi, S., Raub, A. G., Chen, C.-H., Dorn, L. E., Horikoshi, N., Wataksuki, S., Chen, J. K., and Mochly-Rosen, D. (2018) Correcting glucose-6-phosphate dehydrogenase (G6PD) deficiency with a small molecule activator. Nat. Commun. 9: 4045. [PubMed]
2015
Mruk K. and Chen, J. K. (2015) Thinking big with small molecules. J. Cell Biol. 209: 7-9. [PubMed]
Graduate Work
Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH Jr. (2016) Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys. 42:351-70 [Pubmed]
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Mruk K, Kobertz WR. (2015) Bioreactive Tethers Adv Exp Med Biol. 869:77-100. [Pubmed]
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Mruk K, Farley BM, Ritacco AW, Kobertz WR. (2014) Calmodulin meta-analysis: predicting calmodulin binding via canonical motif clustering. J Gen Physiol. 144:105-14. [Pubmed]
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Mruk K, Shandilya SM, Blaustein RO, Schiffer CA, Kobertz WR. (2012) Structural insights into neuronal K+ channel-calmodulin complexes. PNAS 109:1357-83. [Pubmed]
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O'Connell D, Mruk K, Rocheleau JM, Kobertz WR. (2011) Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings. J Gen Physiol. 138:271-7. [Pubmed]
Mruk K, Kobertz WR. (2009) PLoS One. 4:e4236. [Pubmed]
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Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK. (2005) PNAS 102:18099-104. [Pubmed]
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Contact Us
Email:
Office: (307) 766-6481