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Welcome to the Mruk Lab

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People

Karen Mruk

PI

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Natalie Clark

Medical Student

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Patrick Garrett

PhD Student, Neuroscience

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Payge Hoffman

PharmD Student

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Kathryn Lorbacher

PhD student, Pharmacology and Toxicology

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Tom Rynes

Lab Manager
aka
"Renaissance Man"

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Publications

2024

Osman, EA, Rynes, TP, Wang, YL, Mruk, K and McKeague M. Non-invasive single cell aptasensing in live cells and animals. Chemical Science (2024) [Pubmed]

Purifoy, EJ and Mruk, K. Differential roles of diet on development and spinal cord regeneration in larval zebrafish Zebrafish (2024) [Pubmed]

2023

Underwood, KL,* Walker, WJ,* Garret, PI, Linch, S, Rynes, TP, and Mruk, K. Optimizing spinal cord injury in zebrafish larvae: effects of age on the injury response (2023)  bioRxiv

2022

Williams, R.E.; Mruk, K. Aquatic Freshwater Vertebrate Models of Epilepsy Pathology: Past Discoveries and Future Directions for Therapeutic Discovery. Int. J. Mol. Sci. 2022, 23, 8608. [Pubmed]

2020

Mruk, K.*, Ciepla, P., Piza, P. A., Alnaqib, M. A., and Chen, J. K.* (2020) Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development, 147: dev183640 [Pubmed]

2018

Hwang, S., Mruk, K., Rahighi, S., Raub, A. G., Chen, C.-H., Dorn, L. E., Horikoshi, N., Wataksuki, S., Chen, J. K., and Mochly-Rosen, D. (2018) Correcting glucose-6-phosphate dehydrogenase (G6PD) deficiency with a small molecule activator. Nat. Commun. 9: 4045. [PubMed]

2015

Mruk K. and Chen, J. K. (2015) Thinking big with small molecules. J. Cell Biol. 209: 7-9. [PubMed]

Previous Work

Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH Jr. (2016) Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys. 42:351-70 [Pubmed]

Mruk K, Kobertz WR. (2015) Bioreactive Tethers Adv Exp Med Biol. 869:77-100. [Pubmed]

Mruk K, Farley BM, Ritacco AW, Kobertz WR. (2014) Calmodulin meta-analysis: predicting calmodulin binding via canonical motif clustering. J Gen Physiol. 144:105-14. [Pubmed]

Mruk K, Shandilya SM, Blaustein RO, Schiffer CA, Kobertz WR. (2012) Structural insights into neuronal K+ channel-calmodulin complexes. PNAS 109:1357-83. [Pubmed]

O'Connell D, Mruk K, Rocheleau JM, Kobertz WR. (2011) Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings. J Gen Physiol. 138:271-7. [Pubmed]

Mruk K, Kobertz WR. (2009) PLoS One. 4:e4236. [Pubmed]

Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK. (2005) PNAS 102:18099-104. [Pubmed]


Contact Us

East Carolina University
Brody School of Medicine
Department of Pharmacology and Toxicology
600 Moye Boulevard
Greenville, NC 27834

Office: (252) 744-1171

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