Publications
2026
Lorbacher KB, Le, Tram, Milton ME, Mruk, K. Beneath the Surface: Aquatic Models Illuminate Host-Microbe Interactions Biology (2026).
Kinzy TG, Asowata OA, Cruz, LA, Waksmunski AR, Cai J, Mehta P, Mitchell SL, Svaren L, Aboobakar IF, Alimi AA, Jenness D, Bauer A, Nealon CL, Halladay CW, McIntosh BL, Wu WC, Pasquale LR, Hauser MA, Williams SM, Hysi P, Khawaja AP, Wiggs JL, Crawford DC, Stamer WD, Peachey NS, Iyengar SK, Mruk K, Liu Y, Segrè AV, Cooke Bailey JN; Million Veteran Program, MVP Program Office; MVP Steering Committee; MVP Co-Principal Investigators; MVP Core Operations A Primary Open-Angle Glaucoma Locus Near Transcription Factor PRRX1 Identified in the Million Veteran Program Opthalmology Science (2026). [Pubmed]
Rynes, T.P., Osman, E.A., McKeague, M, Mruk, K. (2026) Tunable gene expression in zebrafish using RiboSCALE. bioRxiv
2025
Walker, WJ, Underwood, KL*, Garrett, PI*, Lorbacher, KB, Linch, SM, Rynes, TP, Sloop, C, and Mruk, K. Effects of age on the response to spinal cord injury: optimizing the larval zebrafish model Developmental Biology (2025) [Pubmed]
Gaddy KE, Septer, AN, Mruk, K, and Milton, ME. A mutualistic model bacterium is lethal to non-symbiotic hosts via the type VI secretion system mBio (2025) [Pubmed]
2024
Hoffman, P, Clark, NL, and Mruk, K. Effect of Voltage-Gated K+ Channel Inhibition by 4-aminopyridine in Spinal Cord Injury Recovery in Zebrafish (2024) bioRxiv
Osman, EA, Rynes, TP, Wang, YL, Mruk, K and McKeague M. Non-invasive single cell aptasensing in live cells and animals. Chemical Science (2024) [Pubmed]
Purifoy, EJ and Mruk, K. Differential roles of diet on development and spinal cord regeneration in larval zebrafish Zebrafish (2024) [Pubmed]
2022
Williams, R.E.; Mruk, K. Aquatic Freshwater Vertebrate Models of Epilepsy Pathology: Past Discoveries and Future Directions for Therapeutic Discovery. Int. J. Mol. Sci. 2022, 23, 8608. [Pubmed]
2020
Mruk, K.*, Ciepla, P., Piza, P. A., Alnaqib, M. A., and Chen, J. K.* (2020) Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development, 147: dev183640 [Pubmed]
2018
Hwang, S., Mruk, K., Rahighi, S., Raub, A. G., Chen, C.-H., Dorn, L. E., Horikoshi, N., Wataksuki, S., Chen, J. K., and Mochly-Rosen, D. (2018) Correcting glucose-6-phosphate dehydrogenase (G6PD) deficiency with a small molecule activator. Nat. Commun. 9: 4045. [PubMed]
Previous Work from Dr. Mruk
Mruk K. and Chen, J. K. (2015) Thinking big with small molecules. J. Cell Biol. 209: 7-9. [PubMed]
Kubat Öktem E, Mruk K, Chang J, Akin A, Kobertz WR, Brown RH Jr. (2016) Mutant SOD1 protein increases Nav1.3 channel excitability. J Biol Phys. 42:351-70 [Pubmed]
Mruk K, Kobertz WR. (2015) Bioreactive Tethers Adv Exp Med Biol. 869:77-100. [Pubmed]
Mruk K, Farley BM, Ritacco AW, Kobertz WR. (2014) Calmodulin meta-analysis: predicting calmodulin binding via canonical motif clustering. J Gen Physiol. 144:105-14. [Pubmed]
Mruk K, Shandilya SM, Blaustein RO, Schiffer CA, Kobertz WR. (2012) Structural insights into neuronal K+ channel-calmodulin complexes. PNAS 109:1357-83. [Pubmed]
O'Connell D, Mruk K, Rocheleau JM, Kobertz WR. (2011) Xenopus laevis oocytes infected with multi-drug-resistant bacteria: implications for electrical recordings. J Gen Physiol. 138:271-7. [Pubmed]
Mruk K, Kobertz WR. (2009) PLoS One. 4:e4236. [Pubmed]
Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK. (2005) PNAS 102:18099-104. [Pubmed]